What is your role in the classroom? Are you student teaching or doing an observation? Are you a paraprofessional? Are you the teacher? If you are the assistant or student teacher, talk to the teacher and ask for her advice. Basic subjects that are taught in a middle school life skills classroom are Math, Language Arts, Social Skills, Functional Skills (taking care of self, independence skills, community functioning,etc), and possibly science, social studies, health, etc depending on your district. For students who are typically in life skills classes, independence is a major goal. This includes personal responsibility, taking care of themselves- hygiene, laundry, cleaning, money skills, telling time and time management, being able to function in the community by taking public transportation, going somewhere, purchasing items, making choices, etc. You can find lesson plans based on what you are focusing on in class. All academics are generally functional in a life skills class and should be related to real life as much as possible to benefit their quality of independent functioning in the future. Some companies that have different materials for students with disabilities are

You can also google the following companies and terms to find more information:
Mayer Johnson Company
EDMARK (reading, math, etc systems)
Touch Money
Touch Math
Lesson Plans for life skills students
Community Based Instruction